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KMID : 0361119940080010073
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Korean Journal of Transplantation
1994 Volume.8 No. 1 p.73 ~ p.78
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Liver Transplantation in Rat
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정중기/Chung, Jung Kee
서준석/홍인규/권오중/서경석/김상준/이건욱/Suh, Jun Suk/Hong, In Kyu/Kwon, Oh Joong/Suh, Kyung Suk/Kim, Sang Joon/Lee, Kun Wook
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Abstract
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Rat liver transplantation is a basic model in research of OLT. But surgical technique for OLT is very difficult especially in small vessel anastomosis, After usage of cuff on portal vein and caval vein anastomosis operation time become shortened and survival rate was improved to enable this model available to research work.
Authors made this preliminary trial of rat OLT model and check the relations between survival rate and several conditions of operation time.
1) Concerning donor operation time, survival rate (SR) in above 10 minute group, above 20 minute group were 66.7% and 26.7% in each.
2) Concerning cuff preparation time, SR in above 10 minute group, above 20 minute group were 15.4% and 9.9% in each.
3) Concerning recipient operation time, SR in less than 50 minute group, less than 60 minute group and more than 60 minute group were 100%, 21.4% and 8% in each.
4) In anhepatic time, SR in less than 20 minute group, less than 30 minute group and more than 30 minute group were 66.7%, 26.7% and 0% in each.
5) In ischemic tiem, SR in less than 1 hour group, less than 2 hour group, less than 3 hour group and more than 3 hour group were 50%, 26.7%, 4.8% and 0% in each.
6) SR in early, middle and late stage of research were 0%, 10% and 50% in each In conclusion, reduction of operation time was highly correlated to better survival rates if operation techniques were safe and standardized and to become a research model, highly experienced skill is needed.
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KEYWORD
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